In conclusion, there appears to be a consensus on the importance of balancing properties in drug design. However, we believe that oversimplified strategies with biases for individual parameter ranges and/or directionality for parameter improvement are less efficient at achieving this. While the impact of lipophilicity on individual parameters is well documented in the literature and generally well-embraced, the extent to which these effects tend to offset when fully integrated into the resulting efficacious dose seems to be underappreciated.
This is the challenging and complex nature of drug design: the need to optimize many parameter values relative to each other. While these strategies can appear more complex and difficult to execute, in our experience they are also more likely to result in both improved success and enhanced efficiency in drug discovery.
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