Blog - Pharmacelera - Find larger chemical diversity

Computational Chemistry in Blood Brain Barrier penetration for CNS Drug Discovery

Posted on March 9, 2021March 9, 2021

The challenges of CNS Drug Discovery In the last decades, few clinically active drugs for brain disorders were identified, and many research projects have been abandoned because of drawbacks in the drug discovery pipeline. One of the main CNS drug discovery challenges, is to understand the mechanisms that govern blood–brain barrier permeability. This is mainly due to the physical restriction of the membrane as well as the activity of efflux transporters present, that create an obstacle to drug delivery into […]

News

Pharmacelera Summary 2020

Posted on December 28, 2020January 22, 2021

By Enric Gibert – Jan. 11, 2021 No doubt that 2020 was a challenging year. We sincerely hope you, your colleagues, and family remain safe and healthy and were able to go through the pandemic. However, it has also been Pharmacelera’s best year so far and we look forward to beginning 2021 with energy and […]

Science

The Impact of Lipophilicity and Hydrophobicity in Drug Design

Posted on December 10, 2020December 11, 2020

By Giorgia Zaetta – Dec. 11, 2020 Lipophilicity is the property of a molecule that describes its distribution between water and octanol, and it is the expression of the intermolecular forces that dictate the solvation in the aqueous and organic phases. Lipophilicity and hydrophobicity are often used as equivalent concepts; however, they are not strictly […]

Partnerships

Agreement with Helmholtz Centre for Infection Research

Posted on November 30, 2020December 11, 2020

helmholtz collaboration with Pharmacelera

By Melanie Berg – Nov. 30, 2020 Pharmacelera is proud to announce today, that an agreement was reached with Helmholtz Centre for Infection Research (HZI) for a collaboration. Helmholtz institute for Pharmaceutical Research Saarland (HIPS), which is a branch of the HZI, will utilize PharmScreen®, a field-based high throughput virtual screening software package, to identify […]