Despite the large number of advances in the scientific and technical field underlying the drug discovery process (DNA sequencing, molecular biology, structural biology, HTS, bioinformatics...) as well as the improvements in the management area, the efficiency of the drug discovery R&D has not followed an increasing trend. This observation has been named by Jack W.…Read more
Recent Posts by Alberto
Tautomerism, ionization and chirality are important factors to consider when building a compound library or when finding new hits. Tautomerism and ionization The interactions between a ligand and a target protein can be significantly affected as a result of tautomerism and ionization, potentially having a direct impact when identifying new hits for a given receptor. Hence,…Read more
Professor Javier Luque (h-index of 66), Pharmacelera’s Scientific Director, has received the 10th edition award from the Boschi Gimpera Foundation for his technology transfer efforts from the University of Barcelona to Pharmacelera. Professor Luque has supervised the use of molecular models based on Quantum-Mechanics (QM) computations derived from more than 20 years of research for…Read more
Pim-1 is an oncogene-encoded serine/threonine kinase. Originally identified in Maloney murine leukaemia, it is involved in several cellular functions associated with survival an proliferation which confers a selective advantage during tumorigenesis [1,2]. Given this implication, it has been used as a cancer drug target . IYZ and LY2 are two bioactive inhibitors of Pim-1. The…Read more
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